Friday, April 16, 2021
HMR BCP/BCPO TRPM8
If there was still a purpose in doing the Ig-Nobel thing under current holocaustal circumstances when all science is genocide, this study would qualify. It's a perfectly serious description of a perfectly funny natural phenomenon.
Attraction to feces in wild mammalian species is extremely rare. Here we introduce the horse manure rolling (HMR) behavior of wild giant pandas (Ailuropoda melanoleuca). Pandas not only frequently sniffed and wallowed in fresh horse manure, but also actively rubbed the fecal matter all over their bodies. The frequency of HMR events was highly correlated with an ambient temperature lower than 15 °C. BCP/BCPO (beta-caryophyllene/caryophyllene oxide) in fresh horse manure was found to drive HMR behavior and attenuated the cold sensitivity of mice by directly targeting and inhibiting transient receptor potential melastatin 8 (TRPM8), an archetypical cold-activated ion channel of mammals. Therefore, horse manure containing BCP/BCPO likely bestows the wild giant pandas with cold tolerance at low ambient temperatures. Together, our study described an unusual behavior, identified BCP/BCPO as chemical inhibitors of TRPM8 ion channel, and provided a plausible chemistry-auxiliary mechanism, in which animals might actively seek and utilize potential chemical resources from their habitat for temperature acclimatization.Rolling in shit is ENTERTAINING, no matter how precise and Krautistic the description. It's especially funny when funny critters like pandas do it. Dense jargon and sober acronyms only make it funnier. There's also an ID corollary. Pandas eat nothing but bamboo, which implies that the two must have developed simultaneously. Now we know that pandas roll in horseshit, and dab it all over their fur, which also implies simultaneous development and reliable simultaneous presence in the same place.
Labels: Entertainment, Grand Blueprint
¶ 8:24 AM
