Moreover, neurons in the insular cortex connect to neurons in the amygdala, but the function of this brain connection was previously little studied. The insular cortex being similar between mice and men, the scientists turned to mice for their study. The researchers used light-activated ion channels that were genetically engineered into specific neurons in the brains of mice. This allowed them to switch off the electrical activity of neurons in the insular cortex by shining brief pulses of laser-light during the threat-learning behavior. By switching off the insular cortex during the painful event, the scientists found that mice became essentially fearless against a mild electric shock to the foot. In addition, the ability of the mice to learn from the painful event was greatly reduced.This deserves an illustration because the insula is a tricky piece of geography.
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