The operation of the nervous system has been typically viewed as an intermediary between actively sensing the environment and then actively producing a response. This framework unfortunately ignores the propensity of the brain to generate its own patterned and synchronized activity in the absence of any active input or output.Shouldn't have been surprising.
A major pattern in this regard is the slow oscillation, a rhythm that appears across vast expanses of the forebrain and which entrains other local patterns of population activity. The functional relevance of this input- and output-decoupled slow network rhythm remains a mystery, but one that will probably be solved by an elucidation of both the cellular and the inter-cellular mechanisms giving rise to it in the first place.
What is particularly compelling is that the activity could be not only modulated, but also eliminated or even regenerated by imposed electrical fields. Most shockingly, this activity could be transmitted from one side of a surgically severed slice to the other when the two cut edges were simply placed in close proximity.
Labels: Grand Blueprint
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