To better treat people with depression, not only must we treat the neurons affected by the disease, but we must also restore the integrity of the barrier that regulates exchanges between blood circulation and the brain. Between 30% and 50% of those suffering from depression respond either poorly or not at all to antidepressants," says main author Caroline Ménard, professor at Université Laval's Faculty of Medicine and researcher at the Cervo Brain Research Centre. "This suggests that biological mechanisms other than those directly affecting neurons are at play," adds some asshole who holds a Named Chair at the Centre For Something. Conversely, depressed stressed mice express more of an enzyme called HDAC1 that triggers a loss of claudin-5. "When a chemical compound is used to block HDAC1, the depressive mice produce more claudin-5 and their social interactions spontaneously increase," says some other named-chair asshole who directs some other Centre.No, named-chair assholes. If medication fails, it's not because you haven't broken through the blood-brain barrier to create a complicated chemical reaction in precisely defined proteins and enzymes. It's not working because it's THE WRONG FUCKING ANSWER FROM START TO FINISH. Depression is caused by prolonged and persistent frustration. Repeated attempts to achieve physically impossible goals based on unrealistic expectations. Depression is cured by finding more realistic expectations, and by finding unpunished and unfrustrated ways to DO YOUR DUTY and BE USEFUL. Every living creature has a duty. Every living creature needs to be needed, needs to feel useful. Wrong expectations, formed by reductionist mechanical worldviews, are the main cause of depression. When you start with the genocidal assumption that all creatures are identical passive mechanisms, you will try to do things that are impossible. You will try to ascend the status ladder or achieve power or be liked. When your attempts fail, you will try harder because reductionism tells you that anything is possible if you try hard enough. If you are born with low status and low popularity, those goals are PHYSICALLY IMPOSSIBLE. Attempting to achieve them is SUICIDAL. You need to find your proper unique duty and DO IT. You also need to keep moving and establish a rhythm and resonance. MAKE. WALK.
Labels: From rights to duties, Make or break
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